Applications in Medical Field
Aphios Corporation has developed an improved process utilizing Super fluids™ for the formation of small, uniform liposomes (nanosomes) to improve the delivery and therapeutic efficacy of poorly water-soluble drugs while reducing their toxicities. In Aphios’ Super fluids™ critical fluid nanosome (CFN) process, Super fluids™ at appropriate conditions of pressure and temperature are utilized to solvate phospholipids, cholesterol and other nanosomal raw materials in an apparatus. This Super fluids™ CFN injection technique is ideally suited for the nanoencapsulation of proteins, DNA and small hydrophilic drugs.Super fluids™ CFN evaporation can be uniquely utilized to encapsulate very hydrophobic molecules such as the potent anticancer drug a very effective topoisomerase-I inhibitor and other anticancer and anti-HIV therapeutics. In this technique, the hydrophobic drug(s) are directly solvated in the Super fluids™ prior to injection into a phosphate-buffered saline or other biocompatible solution. After decompression through a nozzle, the Super fluids™ evaporate off leaving an aqueous solution of nanosomes entrapping hydrophobic molecules within their lipid bilayers.Aphios has utilized Super fluids™ CFN to develop nanosomal formulations and other poorly water-soluble therapeutics.